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Top 15 Best CBD Strain for Weight Loss [2023]

The role of cannabis strains in influencing weight is gaining traction in recent research. As many search for natural ways to manage weight, some strains of the cannabis plant stand out as potential appetite suppressants. This article sheds light on the best CBD strains that could potentially help in weight loss, touching on their origins, effects on the endocannabinoid system, and other health benefits.

Table of Contents:

The Role of Endocannabinoid System in Food Intake:

The endocannabinoid system (ECS) is a complex cell-signaling system identified in the early 1990s by researchers exploring THC, a well-known cannabinoid. The system is named for "endocannabinoids," which are internally produced compounds in the body that interact with cannabinoid receptors. These receptors are present throughout the body, emphasizing the system's vital role in various physiological processes, including food intake and energy balance.

a woman measuring her waist size looking out for weight loss

One might wonder, what exactly ties the endocannabinoid system to one's appetite? Well, it's rooted in the two primary endocannabinoids produced by the body: anandamide and 2-arachidonoylglyerol (2-AG). These endocannabinoids bind to receptors, primarily the CB1 and CB2 receptors. CB1 receptors are predominantly found in the central nervous system and are directly linked to the appetite-stimulating effects of cannabinoids. On the other hand, CB2 receptors are more abundant in the peripheral nervous system, influencing inflammation and pain.

In the context of food intake, the activation of CB1 receptors in the brain can stimulate appetite. This is particularly evident in cannabis users. THC, found abundantly in the cannabis plant, binds to CB1 receptors, often leading to the infamous 'munchies.' On the flip side, blocking these receptors can suppress appetite, making CB1 receptor antagonists a topic of interest for weight loss drug administration.

The relationship between the ECS and food intake isn't just about hunger. It's intricately linked to our rewarding system. Studies have found that the ECS plays a significant role in the rewarding properties of food, especially fatty foods. When someone consumes fatty foods, the levels of endocannabinoids in the small intestine increase, which further signals a rewarding sensation in the brain.

Furthermore, the ECS also interacts with other systems in the body that regulate metabolism. For example, it plays a role in fat storage, with the potential to influence body weight. A healthy diet, balanced in essential fatty acids, is believed to support the endocannabinoid system. It's noteworthy that imbalances in this system might contribute to various health conditions, including metabolic disorders, obesity, and more.

For individuals looking into medical marijuana for conditions like chronic pain, it's essential to be aware of these appetite effects. For instance, a strain like Durban Poison, originating from South Africa, is known not just for pain relief but also for its potential as an appetite suppressant. This strain, among others, might be beneficial for those aiming to regulate their food intake while reaping the health benefits of cannabis. For more specific guidance, a consultation at ARCannabisClinic's Marijuana Therapy might offer insights tailored to individual needs.

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For a comprehensive understanding of how cannabinoids work in our system, one might refer to this research article detailing the intricacies of the ECS and its impact on human health.

Key Takeaway: The endocannabinoid system plays a crucial role in regulating appetite and food intake, influencing our body's metabolic processes. This system's modulation can have profound implications for weight management, offering a promising avenue for those seeking balance in their dietary habits and overall health.

Origins and Effects of Durban Poison and Other Strains:

Durban Poison is a unique and potent sativa strain, originating from the South African port city of Durban. For decades, this strain has been appreciated for its spicy, sweet aroma and uplifting effects. Its history stretches back to the ancient traditions of cannabis cultivation in Africa, finding its way to the global cannabis community and becoming an essential part of the modern marijuana lexicon.

Marijuana strains dried cannabis medical marijuana on top of wood background

Cannabis strains that have been cited for their potential in aiding weight loss typically contain higher levels of tetrahydrocannabivarin (THCV), a cannabinoid known to suppress appetite. Here's a list of strains that are either high in THCV or have been popularly used by individuals aiming to manage their weight:

  1. Durban Poison: A pure sativa known for its uplifting effects. It's one of the most popular strains containing a higher level of THCV.

  2. Jack the Ripper: This strain is a combination of Jack’s Cleaner and Space Queen, known for its energizing effects and high THCV content.

  3. Girl Scout Cookies (GSC): Though famous for its potent effects, certain phenotypes are also high in THCV.

  4. Douglas Fir: A pungent strain that's a cross between Granddaddy Purple and SFV OG.

  5. Red Congolese: An African sativa strain, it's often used for focus and mental clarity as well as appetite suppression.

  6. Power Plant: Originating from South Africa, this strain has a sharp, peppery taste.

  7. Skunk #1: While not the highest in THCV, it's a balanced hybrid that some users find helps with weight management.

  8. Moby Dick: Known for its high THC content, it’s also been recognized for its THCV levels.

  9. African: As the name suggests, it originates from Africa and is known to have a reasonable THCV content.

  10. Cherry Pie: A hybrid of Granddaddy Purple and Durban Poison, it’s been popular for relaxation and appetite suppression.

  11. Pineapple Purps: This strain is unique for its higher THCV content, offering more energetic and euphoric effects.

  12. Dutch Treat: A favorite for its sweet and piney flavor, it’s also been used for appetite suppression.

  13. Blue Dream: While it's known more for its calming effects, some users find it useful for weight management.

  14. Willie Nelson: This sativa is another strain chosen by some for its potential appetite-suppressing qualities.

  15. Harlequin: A CBD-rich strain, while it doesn't have a high THCV content, some users find the high CBD content helps them with weight management due to reduced anxiety-driven eating.

The Durban Poison strain is particularly known for its clear, focused energy it bestows upon its users. This makes it a favorite among those who are looking for a productive day or seeking a mental boost without the sedative effects of some other strains. Additionally, it offers significant relief from stress, anxiety, and depression, creating a sense of happiness and euphoria. Leafly has a comprehensive profile on its unique terpene blend, contributing to its distinctive taste and aroma.

Furthermore, Durban Poison is often chosen by patients at medical marijuana dispensaries for its potential therapeutic benefits. It's not just a recreational favorite; it holds prominence in the medical community due to its potential in treating a range of conditions including chronic pain, migraines, and fatigue.

As with any strain, moderation is crucial. Users should be aware of its potency and start with smaller doses, especially if they're new to this particular strain or cannabis in general. It's essential to be informed and understand the specific effects and potential benefits, ensuring a safe and enjoyable experience.

Key Takeaway: Durban Poison is a renowned sativa strain, prized for its clear-headed energy and potential therapeutic benefits. Originating from South Africa, it has made a significant mark on the global cannabis scene due to its unique aroma, taste, and potent effects.

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The Relationship Between Chronic Pain and Weight Gain:

Chronic pain, a persistent and debilitating ailment, often takes a significant toll on the individual's overall well-being. This pain, persisting for weeks to years, not only affects the physical aspects of health but also intertwines with psychological factors, often leading to weight gain. Understanding the link between these two seemingly distinct conditions is crucial for comprehensive health management.

a woman standing in front of a mirror grabbing overweight unhappy face

The mechanics behind chronic pain contributing to weight gain can be multifaceted. Initially, those with persistent pain might find it challenging to engage in regular physical activity. The discomfort often discourages individuals from participating in exercises that might exacerbate their condition. Over time, this lack of movement can result in muscle atrophy and decreased metabolic rate, which naturally leads to weight accumulation.

Moreover, the emotional strain caused by chronic pain can trigger stress-eating or overindulgence in comfort foods, particularly those high in sugars and fats. According to WebMD, emotional eating due to stress or pain can be a significant contributor to unexpected weight gain.

Medications, often prescribed to manage chronic pain, can have side effects that promote weight gain. Some medications might increase appetite, slow down metabolism, or cause water retention, further complicating the weight management process.

Beyond the physiological aspects, the psychological toll is undeniable. Chronic pain often brings about feelings of despair, anxiety, or depression. These feelings, in turn, can alter eating habits, sleep patterns, and general motivation — all factors contributing to weight changes.

Fortunately, modern therapeutic approaches, such as those found at marijuana therapy, provide alternative relief methods for chronic pain, aiming to address the pain source without the side effects that contribute to weight gain.

Key Takeaway: Chronic pain and weight gain are intricately linked through a combination of physical inactivity, emotional responses, and medication side effects. Recognizing and addressing these interconnected issues can lead to more effective health and weight management strategies.

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Health Benefits of Cannabis from South Africa:

South Africa boasts a rich tapestry of biodiversity and culture, and among its treasures is the cannabis plant, locally known as "dagga." For centuries, this plant has held a traditional role in various indigenous communities. Recent scientific research has begun to elucidate the numerous health benefits associated with South African cannabis strains.

strains from south africa showing sunset with giraffes

Historically, South African cannabis has been used for its therapeutic properties, ranging from pain management to easing anxiety. The plant's unique compounds, cannabinoids, interact with the human body's endocannabinoid system, thus modulating a range of physiological processes.

Pain management stands at the forefront of cannabis's therapeutic applications. Numerous studies, as cited by Healthline, highlight the efficacy of cannabis in alleviating chronic pain, making it a potential alternative to conventional painkillers. The indigenous communities of South Africa have known and harnessed this benefit for ages, applying cannabis-infused balms and oils to sore muscles and joints.

Furthermore, South African cannabis strains might aid in the mitigation of mood disorders. Those grappling with conditions such as anxiety and depression might find relief in certain cannabis strains that boast mood-stabilizing properties. The calming effects are often attributed to the plant's ability to interact with serotonin receptors in the brain, which play a pivotal role in mood regulation.

Another pivotal health benefit revolves around its anti-inflammatory properties. Inflammation is a bodily response to injury or illness but, when unchecked, can lead to chronic diseases such as arthritis or Crohn's disease. Certain compounds in cannabis, particularly cannabidiol (CBD), have shown promise in reducing inflammation, paving the way for improved quality of life for those with inflammatory conditions.

It's worth noting that while cannabis holds potential therapeutic benefits, its use should be approached with caution and ideally under professional guidance. The medical screening process can assist potential users in determining if cannabis is a suitable therapeutic option for them.

Key Takeaway: South African cannabis, rooted deeply in indigenous practices, presents a plethora of health benefits, from pain management to mood stabilization. Modern science continues to validate what traditional communities have known for centuries, highlighting the plant's therapeutic potential.

Tweet-worthy message: "South African cannabis, rich in tradition and therapeutic promise, stands as a testament to nature's bounty. Dive into the benefits with @ARCannabisclin1. 🍃 #SouthAfricanCannabis #TherapeuticCannabis #TraditionalMedicine" Tweet this!

Heart Disease, Cannabis Users, and Body Weight:

Heart disease remains a global health concern, with countless research being directed towards its understanding and prevention. In recent years, attention has been drawn to the possible connections between heart disease, cannabis use, and body weight. It's a complex nexus, deserving a comprehensive look.

a woman standing on a scale with tape measure

To begin with, heart disease is multifaceted, often stemming from factors such as genetics, lifestyle choices, and existing health conditions. Among these, body weight plays a significant role. Obesity, with its attendant risks, has been conclusively linked to heart disease. The excess weight places strain on the heart, leading to conditions such as hypertension, which, if unchecked, escalate into graver issues like cardiac arrest or stroke.

Cannabis use, on the other hand, has been historically associated with an increased appetite. Commonly referred to as the "munchies," this phenomenon sees cannabis users experience heightened food cravings. However, paradoxically, a study published by the American Journal of Epidemiology found that cannabis users generally have a lower body mass index (BMI) than non-users. The underlying reasons remain a topic of debate, but some postulate that cannabis might influence metabolic processes in a way that promotes weight loss or maintenance.

Now, while a lower BMI might seem like a protective factor against heart disease, it's essential to remember that cannabis also has direct cardiovascular effects. Some studies have pointed out that cannabis can cause short-term increases in heart rate and blood pressure, potentially aggravating conditions for those already at risk of heart disease. Moreover, certain compounds in cannabis might interact with heart medications, underscoring the need for medical consultation for those considering its use.

For those interested in exploring the therapeutic potentials of cannabis, especially with heart conditions in the backdrop, a medical screening becomes imperative. It ensures that the benefits derived align well with one's health profile.

Key Takeaway: The relationship between heart disease, cannabis, and body weight is intricate. While cannabis users might often exhibit a lower BMI, the plant's direct cardiovascular effects necessitate a cautious and informed approach, especially for those with pre-existing heart conditions.

Tweet-worthy message: "While the connection between cannabis use and body weight poses intriguing findings, it's pivotal to approach its use with heart health in mind. Dive into the complexities with @ARCannabisclin1. 🍃 #HeartHealth #CannabisResearch" Tweet this!


What strains of cannabis are most known for appetite suppression? Several strains, notably Durban Poison and some sativa-dominant hybrids from South Africa, have been recognized for their potential appetite-suppressing properties.

How do CBD strains interact with the endocannabinoid system to aid weight loss? CBD strains interact with the body's cannabinoid receptors, which can influence metabolism and food intake, thereby potentially aiding in weight loss.

Are there specific cannabinoid receptors associated with weight loss? Yes, CB1 and CB2 are the primary cannabinoid receptors in the endocannabinoid system, with CB1 mainly influencing appetite and food intake.

Do indica strains or sativa strains have a more pronounced effect on weight loss? Typically, sativa strains, especially those like Durban Poison, are more associated with energy boosts and appetite suppression, making them more sought after for weight loss purposes.

Can CBD oil be used as an appetite suppressant? Yes, the best CBD oil, especially full-spectrum CBD oil, can have appetite suppressant effects, although individual results might vary.

How does the THC content in a strain influence weight loss? Higher doses of THC can stimulate appetite, while strains with a balance of THC and THCV, like Durban Poison, might offer appetite-suppressing benefits.

Are there strains specifically grown in South Africa known for weight loss? Yes, strains like Durban Poison, native to South Africa, are particularly noted for their potential weight loss benefits due to their energizing and appetite-curbing properties.

How do CBD strains assist in managing heart disease risks? CBD strains can potentially lead to a lower BMI, reducing risks associated with heart disease, such as high blood pressure.

Is it safe to combine CBD strains with other weight loss supplements? It's crucial to consult a healthcare professional before combining CBD strains with other dietary supplements to ensure safety and avoid potential drug interactions.

How do higher doses of CBD influence food intake? Higher doses of CBD might reduce food intake by interacting with cannabinoid receptors that modulate hunger and satiety signals.

Are there specific cannabinoid research studies focused on weight loss? Yes, current research is delving into how cannabinoids, particularly CBD and THCV, interact with the endocannabinoid system to influence body weight and metabolism.

Is there a difference between hemp-derived CBD products and marijuana strains for weight loss? Hemp-derived CBD products typically have little to no THC content. While they can offer health benefits, marijuana strains might have a more pronounced effect on appetite and metabolism due to their varied cannabinoid profiles.

Do CBD strains help with metabolic syndrome? Some preliminary studies and anecdotal evidence suggest that CBD strains can help regulate metabolic disorders, but more research is needed to establish this conclusively.

What are the potential side effects of using CBD strains for weight loss? Potential side effects can include changes in appetite, dry mouth, and dizziness. Always consult with a healthcare provider before starting a CBD regimen for weight loss.

Can CBD strains influence insulin resistance in users? There is some evidence to suggest that CBD might help improve insulin resistance, although more studies are needed to confirm these findings conclusively.

What's the role of brown fat cells in weight loss concerning CBD strains? Brown fat cells burn energy, promoting calorie expenditure. Some research suggests CBD might promote the conversion of white fat cells to brown, thereby potentially aiding weight loss.

How does the nervous system interact with CBD strains in the context of weight management? The endocannabinoid system, part of the nervous system, plays a crucial role in regulating metabolism and appetite. CBD strains interact with this system, potentially influencing weight management.

Is there a difference in weight loss effects between full-spectrum CBD oil and isolate CBD oil? Full-spectrum CBD oil contains all cannabinoids, terpenes, and flavonoids from the cannabis plant, potentially offering an "entourage effect." This might be more effective for weight management than isolate CBD oil, which contains only CBD.

How does sour tsunami, a CBD strain, influence weight loss? Sour Tsunami is a high-CBD strain. While it offers several health benefits, its direct influence on weight loss needs further research.

Can cannabinoid products like CBD oil replace traditional weight loss medications? While CBD products offer potential weight loss benefits, it's essential to consult with healthcare professionals before replacing or combining them with traditional weight loss medications.


As the awareness around CBD strains and their potential benefits for weight loss grows, so does the need for clear guidance and expert opinion in the domain. ARCannabisClinic, a leading national network, provides patients legal access to medical marijuana in the United States. With their industry-leading MMJ Therapy Visit, patients receive a tailored consultation with a cannabis expert, leading to a comprehensive medical marijuana treatment plan. As pioneers in full diagnosis evaluations, ARCannabisClinic is dedicated to aiding patients with PTSD, anxiety, and other medical conditions. The need for gathering external medical records is eliminated, simplifying the process for patients. As the realm of medical marijuana expands, seeking guidance from reputable entities like ARCannabisClinic is paramount for safe and effective usage.

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